| 摘要 |
Cyclic disulfide derivatives represented by general formula (I), wherein R<1>, R<2> and R<3> represent each H or alkyl; m is 0 or 1, and n is 1 or 2. Because of having effects of inhibiting neovascularization, regulating vascular permeability and preventing vascular endothelial growth factor from releasing, these compounds are expected as being useful as remedies for diseases in which neovascularization, vascular permeability or vascular endothelial growth factor participates, in particular, retinal diseases such as diabetic retinopathy, macular degeneration, retinal venous obliteration and retinal arterial obliteration, neovascularization glaucoma and tumors such as anginoma.
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