发明名称 |
VERFAHREN ZUR HERSTELLUNG VON ZWISCHENPRODUKTEN ZUR SYNTHESE VON ANTIMYKOTIKA |
摘要 |
<p>Disclosed is a process for preparing chiral compounds of the formula (I) <IMAGE> (I) wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula <IMAGE> or <IMAGE> wherein: X1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2OR''; Q* represents a chiral auxiliary group; R'' represents a hydroxy protecting group selected from -CH2C6H5, or -C(O)R1, wherein R1 is C1-C6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.</p> |
申请公布号 |
AT182146(T) |
申请公布日期 |
1999.07.15 |
申请号 |
AT19940915399T |
申请日期 |
1994.04.28 |
申请人 |
SCHERING CORPORATION |
发明人 |
SAKSENA, ANIL, K.;GIRIJAVALLABHAN, VIYYOOR, M.;PIKE, RUSSELL E.;WANG, HAIYAN;LOVEY, RAYMOND, G.;LIU, YI-TSUNG;GANGULY, ASHIT, K.;MORGAN, WILLIAM, BRIAN;ZAKS, ALEKSEY |
分类号 |
C07C69/63;C07C69/65;C07D263/26;C07D307/12;C07D405/06;C07D413/06;C07D417/06;C07D521/00;C12P7/04;C12P7/62;C12P41/00;(IPC1-7):C07D405/06 |
主分类号 |
C07C69/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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