发明名称 |
SOLID SUPPORTED SYNTHESIS OF HYDROXAMIC ACIDS |
摘要 |
The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.
|
申请公布号 |
WO9935126(A1) |
申请公布日期 |
1999.07.15 |
申请号 |
WO1998IB02117 |
申请日期 |
1998.12.28 |
申请人 |
THE PROCTER & GAMBLE COMPANY;GOLEBIOWSKI, ADAM;KLOPFENSTEIN, SEAN, REES |
发明人 |
GOLEBIOWSKI, ADAM;KLOPFENSTEIN, SEAN, REES |
分类号 |
C07C259/04;C07B61/00;C07C259/06;C07C259/10;C07C319/20;C07C323/62;C07D307/68;(IPC1-7):C07C259/04 |
主分类号 |
C07C259/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|