发明名称 ANTIMICROBIAL CARBAPENEM QUINOLONES
摘要 <p>Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: <CHEM> wherein (1) A<1>, A<2>, A<3>, R<1>, R<4> and R<6> generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have animicrobial activity; and (2) R<1> or R<3> contain a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula: <CHEM> wherein (3) R<1><0>, R<1><1>, R<1><2>, R<1><3>, and R<1><4>, together with bonds "a" and "b", form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and (4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, phosphone, phosphoramide, phosphate, sulfonamide, ester, thioester, amide, and hydrazide groups.</p>
申请公布号 KR100211005(B1) 申请公布日期 1999.07.15
申请号 KR19980048320 申请日期 1998.11.12
申请人 NORWICH EATON PHARMACEUTICALS INC. 发明人 DEMUTH JR, THOMAS PROSSER;WHITE, RONALD EUGENE
分类号 C07D499/897;A61K31/431;A61K31/47;A61K31/535;A61K31/545;A61K31/546;A61P31/04;A61P43/00;C07D215/56;C07D401/04;C07D401/12;C07D401/14;C07D409/12;C07D417/12;C07D417/14;C07D455/04;C07D463/00;C07D463/16;C07D471/04;C07D477/10;C07D477/14;C07D477/20;C07D487/04;C07D498/04;C07D498/06;C07D499/00;C07D499/04;C07D499/86;C07D499/87;C07D499/88;C07D501/00;C07D501/18;C07D501/20;C07D501/34;C07D503/00;C07D505/00;C07D513/04;C07D513/06;C07D513/16;C07D519/00;C07D519/06;C07D521/00;C07F9/6561;(IPC1-7):C07D477/14 主分类号 C07D499/897
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