| 发明名称 |
IMPROVED PSEUDOMONAS EXOTOXINS OF LOW ANIMAL TOXICITY AND HIGH CYTOCIDAL ACTIVITY |
| 摘要 |
<p>Improved Pseudomonas exotoxins of low animal toxicity and high cytocidal activity are described. Substitution of positively charged amino acid residues with an amino acid residue without a positive charge provides markedly changed exotoxins. Conjugation of the new exotoxins with suitable targeting agents provides cytocidal specificity for killing desired cellular entities.</p> |
| 申请公布号 |
EP0531434(B1) |
申请公布日期 |
1999.07.14 |
| 申请号 |
EP19910911177 |
申请日期 |
1991.05.10 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY UNITED STATES DEPARTMENT OF COMMERCE |
发明人 |
PASTAN, IRA;FITZGERALD, DAVID;CHAUDHARY, VIJAY |
| 分类号 |
A61K38/00;A61K31/00;A61K35/74;A61K38/22;A61K39/00;A61K39/395;A61P35/00;A61P43/00;C07K14/195;C07K14/21;C07K14/41;C07K14/495;C07K14/52;C07K14/54;C07K14/73;C07K19/00;C12N15/09;C12N15/31;C12P21/00;C12P21/02;C12R1/19;C12R1/38;(IPC1-7):C12N15/31;C12N15/62;C07K14/00;A61K47/48 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
