发明名称 |
COMPOSITION CONTAINING WATER SOLUBLE ANTITUMOR MEDICAMENT PACLITAXEL |
摘要 |
<p>Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, autoimmune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.</p> |
申请公布号 |
CZ9802908(A3) |
申请公布日期 |
1999.07.14 |
申请号 |
CZ19980002908 |
申请日期 |
1997.03.11 |
申请人 |
PG-TXL COMPANY |
发明人 |
LI CHUN;WALLACE SIDNEY;YU DONG-FANG |
分类号 |
A61K31/335;A61K31/337;A61K31/47;A61K31/4738;A61K31/4745;A61K31/70;A61K31/7042;A61K31/7048;A61K47/48;A61K51/00;A61K51/04;A61L31/10;A61L31/16;A61P9/00;A61P35/00;A61P37/02;A61P43/00;(IPC1-7):A61K51/00;A61M36/00;A01N43/02;C07D305/00 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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