发明名称 |
Oligonucleotide modulation of protein kinase C |
摘要 |
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
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申请公布号 |
US5922686(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19960664336 |
申请日期 |
1996.06.14 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
BENNETT, C. FRANK;DEAN, NICHOLAS |
分类号 |
A61K38/00;A61K48/00;C07H21/00;C07K14/705;C12N9/12;C12N15/113;C12Q1/68;(IPC1-7):A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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