发明名称 |
Dye-labeled antibody conjugate and preparation method thereof |
摘要 |
The invention relates to a dye-labeled antibody conjugate comprising an antibody conjugate and a cyanine dye. The dye-labeled antibody conjugate is prepared by polymerizing an antibody such as mouse IgG in phosphate buffer using a polyfunctional reagent such as dithiobis(sulfosuccinimidylpropionate), and stirring the antibody and a cyanine dye represented by Formula I . The dye-labeled antibody conjugate is more sensitive to antigens than conventional dye-labeled antibodies because it has many reactive sites to antigens. wherein X represents a halogen, M represents a hydrogen or alkali metal, and n represents an integer of 1 to 4
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申请公布号 |
US5922618(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19970831204 |
申请日期 |
1997.04.02 |
申请人 |
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. |
发明人 |
SHIGETOU, NOBUYUKI;MIYAZAKI, JINSEI;HIRAI, MAHITO |
分类号 |
G01N33/532;G01N33/58;(IPC1-7):G01N33/549;C07K16/00 |
主分类号 |
G01N33/532 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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