发明名称 |
Preparation of oxymorphone from morphine |
摘要 |
A process is provided for preparing oxymorphone from morphine by: (a) reacting morphine with an acyl halide or anhydride to form 3-acylmorphine, or (b) reacting morphine with benzyl-halide to form 3-benzylmorphine, and thereafter either by (3a) or (3b): (3a) introducing a beta -oriented hydroxy group at the 14-position of the 3-acyl- or 3-benzyl-morphinone with aqueous hydrogen peroxide and an acid at at temperature of about 15 DEG to about 70 DEG C. to form the 3-acyl or 3-benzyl-14-hydroxymorphinone; (3b) acylating the 3-acyl or 3-benzyl-morphinone with an acylating agent so as to form the dienol acylate followed by oxidizing the dienol acetate to the corresponding 3-acyl or 3-benzyl-14-hydroxymorphinone; (4) hydrogenating the 3-acyl-14-hydroxymorphinone with a catalyst so as to form the 3-acyloxymorphone; (5) hydrolyzing the 3-acyl-oxymorphone with aqueous acidic or basic solution to form oxymorphone; (6) hydrogenating the 3-benzyl-14-hydroxymorphinone with a catalyst so as to form oxymorphone.
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申请公布号 |
US5922876(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19980116284 |
申请日期 |
1998.07.16 |
申请人 |
PENICK CORPORATION |
发明人 |
HUANG, BAO-SHAN;LU, YANSONG;JI, BEN-YI;CHRISTODOULOU, ARIS P |
分类号 |
A61K31/485;A61P25/04;C07D489/02;C07D489/08;(IPC1-7):C07D489/08 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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