发明名称 |
5H-indeno[1,2-b]pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them |
摘要 |
PCT No. PCT/FR95/00359 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26342 PCT Pub. Date Oct. 5, 1995Compounds of formula (I): wherein R represents a CR4R5, CHR6, or C=R7 radical and R3 represents an oxygen atom, salts thereof, the preparation thereof and drugs containing same. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-osoxaziepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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申请公布号 |
US5922716(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19960714164 |
申请日期 |
1996.09.27 |
申请人 |
RHONE-POULENC RORER S.A. |
发明人 |
ALOUP, JEAN-CLAUDE;AUDIAU, FRANCOIS;BARREAU, MICHEL;DAMOUR, DOMINIQUE;GENEVOIS-BORELLA, ARIELLE;JIMONET, PATRICK;MIGNANI, SERGE;RIBEILL, YVES |
分类号 |
C07D241/44;A61K31/495;A61P3/04;A61P9/00;A61P9/08;A61P9/10;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P25/28;A61P29/00;A61P39/02;C07D241/38;C07D487/04;(IPC1-7):C07D487/04;C07D247/02 |
主分类号 |
C07D241/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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