发明名称 Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation
摘要 Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation. The invention relates to the use of xanthine derivatives of the formula I in which R2 is a (C1-C4)-alkyl group and at least one of the symbols R1 and R3 is a radical of the formula II or III in which A is CHOH, CO or dioxolane, R4 is a hydrogen atom or a (C1-C4)-alkyl group and n is 0 to 5, and in which R5 and R6 are hydrogen atoms or (C1-C4)-alkyl groups or, together with the nitrogen atom to which they are bonded, form a 5- to 7-membered ring, it being possible for one carbon atom to be replaced by an oxygen or nitrogen atom, m is 1 or 2 and the other radical R1 or R3, if appropriate, is a hydrogen atom, a (C1-C6)-alkyl group or a (C3-C6)-alkenyl group, for the preparation of medicaments for the prophylaxis and treatment of nerve damage following an interruption in blood circulation, and novel xanthine derivatives, and to processes for their preparation.
申请公布号 US5922868(A) 申请公布日期 1999.07.13
申请号 US19950576936 申请日期 1995.12.22
申请人 HOECHST AKTIENGESELLSCHAFT 发明人 THORWART, WERNER;FURRER, HARALD;WOLF, ERHARD;GEBERT, ULRICH;ROSSMANITH, ERHARD;GROME, JOHN J.;SCHNEIDER, ERNST-JUERGEN
分类号 A61K31/52;A61K31/522;A61P25/02;A61P25/28;C07D473/00;C07D473/06;(IPC1-7):A61K31/52;C07D473/04;C07D473/08 主分类号 A61K31/52
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