| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject inhibitor having excellent promoting effects on melanin production, capable of preventing and improving melanogenetic insufficiency of trichopoliosis, leukoplasia, etc., by including Piper Methysticum or its extract as an active ingredient. SOLUTION: This therapeutic agent comprises Piper Methysticum (a plant of the genus Piper of the family Piperaceae, called 'Kaba' or 'Kawa' in Japanese, herbaceous bush distributed in the Oceania district) or its extract as an active ingredient. The therapeutic agent can be used as it is or formulated with a component useful for a cosmetic, a quasi medicine, a medicine or the like and used. Preferably the inhibitor contains 0.0001-20 wt.% calculated as a dried solid content of the plant in the whole composition. The inhibitor can be used by an application such as oral administration, topical administration, etc., preferably applied to the skin as an external preparation for skin simply. |
