Method and compositions for the synthesis of dioxolane nucleosides with beta configuration

摘要

PCT No. PCT/CA96/00845 Sec. 371 Date Jun. 26, 1997 Sec. 102(e) Date Jun. 26, 1997 PCT Filed Dec. 13, 1996 PCT Pub. No. WO97/21706 PCT Pub. Date Jun. 19, 1997The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C. wherein R1 and L are defined herein.