发明名称 |
Composition and method of preparing microparticles of water-insoluble substances |
摘要 |
Submicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage.
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申请公布号 |
US5922355(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19970939699 |
申请日期 |
1997.09.29 |
申请人 |
RESEARCH TRIANGLE PHARMACEUTICALS |
发明人 |
PARIKH, INDU;SELVARAJ, ULAGARAJ |
分类号 |
A61K9/50;A61K9/10;A61K9/14;A61K9/51;A61K47/06;A61K49/00;A61K49/04;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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