| 摘要 |
A compound of formula (I) wherein Ph1, Ph2, and Ph3 are each a phenyl group opti onally substituted with a combination of up to three members of the group consisting of fluoro, chloro, br omo, hydroxy, trifluoromethyl, NH2, N(CH3)2, (C1-4) alkyl and (C1-4)alkoxy or the phenyl group can be substituted with a meth ylenedioxy group; n is an integer of from 1 to 5; m is 0 or an integer of from 1 to 2; and q is an integer of from 1 to 2; o r an acid addition salt thereof, which reverse multidrug resistance in multidrug resistant tumor cells and are thus useful adju vants in the treatment of tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins,
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