| 摘要 |
The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula wherein R1 signifies hydrogen, alkyl, cyclo-alkyl, alkenyl, aryl or an amino protecting group; and R2, R3 each independently signify hydrogen, alkyl, cyclo-alkyl, alkenyl or aryl; by converting a compound of the formula wherein X signifies a protected hydroxy group; in the presence of a primary amine of the formula R1NH2 into the pyrrolidine derivative of the formula wherein X and R1 have the aforementioned significances; which is subsequently reacted in the presence of R2R3NH under pressure; and with the use of this process for the production of vinylpyrrolidinone-cephalosporin derivatives. |
