| 摘要 |
The invention relates to a compound of formula (I) wherein x is S or NH, and Y and Z are each CH; or X is NH and one of variables Y and Z is N and the other is CH; R1 and R2, independently of one another, represent hydrogen, C1-C7alkyl or C1-C7alkyl substituted by hydroxy, halogen, C1-C7alkoxy, carboxy, C1-C7alkoxycarbonyl, carbamoyl, C1-C7alkylcarbamoyl, di-C1-C7alkylcarbamoyl, C3-C8cycloalkyl or by C3-C8cycloalkyl which is substituted by C1-C7alkoxy-carbonyl, or represent C2-C7 alkanoyl; whereas at least one of variables R1 and R2 is different from hydrogen; or the group NR1R2 is linear C2-C6alkyleneamino that is unsubstituted or substituted. The ring A, apart from being substituted by -SO2NR1R2 and -NH-, is unsubstituted or substituted one or more times; the ring B is substituted once or twice via a carbon atom of ring B or a salt thereof, especially a pharamaceutically acceptable salt thereof; to processes for their preparation, to pharmaceutical compositions and to the use of the compounds of formula (I) and their salts. |
