发明名称 METALLOCORRINOIDS AS BIOLOGICALLY COMPATIBLE CARRIERS OF PHARMACOLOGICAL AGENTS
摘要 A purified compolex of a mettallocorrinoid, such as a vitamin B12 compound, and a pharmacological agent, such as nitric oxide, that is capable of site-specifif delivery of the pharmacological agent in vivo. The pharmacological agent is bound to the metallocorrinoid in a non-donating solvent. The complex is then resuspended in a biocompatible medium and inserted into the recipient. The pharmacological agent then releases in vivo, especially under acidic conditions.
申请公布号 WO9933833(A1) 申请公布日期 1999.07.08
申请号 WO1998US27857 申请日期 1998.12.30
申请人 THE UNIVERSITY OF AKRON 发明人 BAUER, JOSEPH, A.
分类号 A61K31/409;A61K31/714;A61P43/00;C07D487/22;(IPC1-7):C07D487/22 主分类号 A61K31/409
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