发明名称 |
SUBSTITUTED beta -ALANINES |
摘要 |
The invention is directed to physiologically active compounds of general formula (I), wherein R<1> is hydrogen, halogen, lower alkyl or lower alkoxy; X<1>, X<2> and X<6> independently represent N or CR<2>; and one of X<3>, X<4> and X<5> represents CR<3> and the others independently represents N or CR<2> [where R<2> is hydrogen, halogen, lower alkyl or lower alkoxy; and R<3> represents a group -L<1>-(CH2)n-C(=O)-N(R<4>)-CH2-CH2-Y]; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4( alpha 4 beta 1).
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申请公布号 |
WO9933789(A1) |
申请公布日期 |
1999.07.08 |
申请号 |
WO1998GB03859 |
申请日期 |
1998.12.23 |
申请人 |
RHONE-POULENC RORER LIMITED;ASTLES, PETER, CHARLES;HARRIS, NEIL, VICTOR;MORLEY, ANDREW, DAVID |
发明人 |
ASTLES, PETER, CHARLES;HARRIS, NEIL, VICTOR;MORLEY, ANDREW, DAVID |
分类号 |
C07D295/12;A61K31/197;A61K31/341;A61K31/357;A61K31/36;A61K31/381;A61K31/40;A61K31/4015;A61K31/4025;A61K31/403;A61K31/404;A61K31/4045;A61K31/4164;A61K31/4178;A61K31/433;A61K31/4402;A61K31/4406;A61K31/4427;A61K31/4439;A61K31/445;A61K31/5375;A61K31/55;A61P9/10;A61P11/06;A61P17/02;A61P29/00;A61P35/04;A61P43/00;C07C229/18;C07C233/47;C07C237/12;C07C237/22;C07C275/42;C07D207/26;C07D207/27;C07D209/08;C07D211/16;C07D213/40;C07D223/10;C07D233/61;C07D285/06;C07D307/52;C07D317/58;C07D333/20;C07D401/12;C07D403/12;C08F8/00;C08F212/14;C40B40/04;C40B40/14;(IPC1-7):C07C275/42;A61K31/17 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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