发明名称 |
USE OF CHELATING AGENTS IN THE TREATMENT OF ATHEROSCLEROTIC CONDITIONS |
摘要 |
The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R<1> independently represents hydrogen or -CH2COR<5>; R<5> represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R<2> independently represents a group XYR<6>; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R<7>; Y represents a bond, an oxygen atom or a group NR<6>; R<6> is a hydrogen atom, a group COOR<8>, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR<8>, CONR<8>2, NR<8>2, OR<8>, =R<8>, =O, OP(O)(OR<8>)R<7> and OSO3M; R<7> is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R<8> is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R<3> represents a C1-8 alkylene group, preferably a C1-6, e.g. a C2-4 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R<4> independently represents hydrogen or C1-3 alkyl; and each R<9> independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl). |
申请公布号 |
WO9933521(A2) |
申请公布日期 |
1999.07.08 |
申请号 |
WO1998GB03839 |
申请日期 |
1998.12.18 |
申请人 |
NYCOMED IMAGING AS;KARLSSON, JAN, OLOF, GUSTAV;ANDERSSON, ROLF, GOERAN, GUSTAV;OLSSON, ANDERS;ZIEDEN, BO;JYNGE, PER;GRIFFITH, TUDOR;GRANT, DEREK;TOWART, ROBERTSON;REFSUM, HELGE |
发明人 |
KARLSSON, JAN, OLOF, GUSTAV;ANDERSSON, ROLF, GOERAN, GUSTAV;OLSSON, ANDERS;ZIEDEN, BO;JYNGE, PER;GRIFFITH, TUDOR;GRANT, DEREK;TOWART, ROBERTSON;REFSUM, HELGE |
分类号 |
A61K31/444;A61K31/198;A61K31/44;A61K31/675;A61P9/10 |
主分类号 |
A61K31/444 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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