发明名称 |
METHODS, SYSTEMS, AND KITS FOR INTRAVASCULAR NUCLEIC ACID DELIVERY |
摘要 |
kucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm<2> to 100 W/cm<2>, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved. |
申请公布号 |
WO9933500(A2) |
申请公布日期 |
1999.07.08 |
申请号 |
WO1998US27852 |
申请日期 |
1998.12.30 |
申请人 |
PHARMASONICS, INC. |
发明人 |
NEWMAN, CHRISTOPHER, M., H.;BRISKEN, AXEL, F. |
分类号 |
A61M5/00;A61B17/22;A61F13/00;A61K9/22;A61M37/00;A61N1/32 |
主分类号 |
A61M5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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