| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel intermediate that is useful for producing a novel erythromycin derivative by introducing a specific chemical structure thereunto. SOLUTION: This compound is represented by formula I-formula IV [R is (CH2 )n Ar1 (X is O, S, SO, SO2 , C=O or the like; Ar2 is an aryl or a heterocyclic aryl or the like); R1 is a residue of readily cleavable group; Z' is a residual group of a carboxylic acid of 18 or less carbon atoms]. The compound of formula I-IV is prepared by allowing a reagent that can selectively activate the hydroxyl group in the 11-position of the compound of formula V to react thereby forming the compound of formula I, allowing a compound of the formula: R-N=C=O to react with the compound of formula II to form the compound of formula III followed by reaction of the product with carbonyl diimidazole to give the objective compound of formula IV. |
