| 摘要 |
PROBLEM TO BE SOLVED: To obtain a reagent for measuring an endotoxin for the diagnoses of gram-negative bacterium-infected diseases and measuring a peptide glucan for the safety tests of medicines, etc., and the microorganism tests of foods, etc., by includingβ-1,3-glucanase. SOLUTION: This reagent for measuring an endotoxin and/or a peptide glucan comprisesβ-1,3-glucanase, and a composition containing the inactivated factors of a body fluid-coagulating system cascade originating from an arthropod or a phenol oxidase precursor cascade and a substance reacting with theβ-1,3- glucanase to activate the cascade. The reagent is useful for measuring the endotoxin to early diagnose septicemia infected with gram-negative bacteria, for measuring the peptide glucan existing in the cell walls of almost all procaryotes to test the safety of medicines, etc., test the presence of microorganisms in water, foods, etc., and diagnose infectious diseases, etc. The endotoxins are lipopolysaccharides existing in the outer cell wall membranes of gram-negative bacteria.
|
