发明名称 |
Non-infectious HIV particles and uses therefor |
摘要 |
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
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申请公布号 |
US5919458(A) |
申请公布日期 |
1999.07.06 |
申请号 |
US19950477081 |
申请日期 |
1995.06.07 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
ALDOVINI, ANNA;YOUNG, RICHARD A.;FEINBERG, MARK B.;TRONO, DIDIER;BALTIMORE, DAVID |
分类号 |
A61K39/00;A61K39/21;A61P31/18;C07K14/16;C12N7/00;C12N7/04;C12N15/867;(IPC1-7):A61K39/21;C12N15/86 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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