发明名称 |
Methods and compositions for the use of apurinic/apyrimidinic endonucleases |
摘要 |
Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.
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申请公布号 |
US5919643(A) |
申请公布日期 |
1999.07.06 |
申请号 |
US19970872719 |
申请日期 |
1997.06.11 |
申请人 |
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE |
发明人 |
KELLEY, MARK R.;DUGUID, JOHN;EBLE, JOHN |
分类号 |
A61K49/00;C07K14/47;C07K16/40;C12N9/22;C12Q1/44;G01N33/50;G01N33/573;G01N33/574;(IPC1-7):C12Q1/44 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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