| 摘要 |
There is provided a system for automatically responding to insulin demand without any need for external monitoring or injecting of insulin into the diabetic patient. The system provides for sensing glucose levels internally, and responding by stimulating either the pancreas or a transplant of pancreatic islets in order to enhance insulin production. The enhancing stimulation is delivered at a rate greater than the burst rate, or is otherwise controlled so that the depolarization burst constitutes a greater portion of each islet electrical cycle, thereby resulting in increased insulin production. The system also provides for continuous glucose monitoring, and reacts to sensed hypoglycemia by delivering stimulus pulses timed to reduce the burst durations, and thus to inhibit insulin production. In another embodiment, the system responds to a good intake signal, either externally or internally generated, by going through a time response algorithm to provide a stimulation-enhanced insulin response which simulates the natural response. In yet another embodiment, the functionality of an islet transplant is continually monitored, and performance data is logged and down loaded on command to an external programmer. The stimulation of patient pancreatic cells may be combined with administration of a hypoglycemic agent.
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