| 发明名称 |
IL-13 receptor specific chimeric proteins |
| 摘要 |
This invention provides chimeric molecules useful for killing tumor cells bearing IL13 receptor(s) (IL-13R). The molecules comprise a cytotoxic molecule attached to a targeting molecule that specifically binds an IL-13 receptor. Preferred targeting molecules include IL-13 and anti-IL-13R antibodies.
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| 申请公布号 |
US5919456(A) |
申请公布日期 |
1999.07.06 |
| 申请号 |
US19970821840 |
申请日期 |
1997.03.21 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PURI, RAJ K.;DEBINSKI, WALDEMAR;PASTAN, IRA;OBIRI, NICHOLAS |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K51/00;A61P35/00;C07K14/21;C07K14/54;C07K16/28;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/24;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
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