| 发明名称 |
Inhibitors of farnesyl-protein transferase |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
US5919785(A) |
申请公布日期 |
1999.07.06 |
| 申请号 |
US19970823921 |
申请日期 |
1997.03.25 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
DINSMORE, CHRISTOPHER J.;WILLIAMS, THERESA M.;BERGMAN, JEFFREY |
| 分类号 |
C07D233/54;C07D401/06;C07D403/06;(IPC1-7):C07D233/54;C07D241/08;A61K31/495;A61K31/415 |
主分类号 |
C07D233/54 |
| 代理机构 |
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