PRODUCTION OF OPTICALLY ACTIVE 2-PIPERAZINECARBOXAMIDE OR ITS SULFATE AND OPTICALLY ACTIVE 2-PIPERAZINECARBOXYLIC ACID OR ITS SALT BY USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a method for simply producing optically active 2- piperadinecarboxamide or its sulfate having high optical purity and a method for producing optically active 2-piperadinecarboxylic acid or its salt by using the prescribed method. SOLUTION: This production of optically active 2-piperadinecarboxyamide or its sulfate comprises dealkylating 2-(N-tert-butylcarbamoyl)piperadine expressed by the formula (R<1> , R<2> and R<3> are each the same or a different alkyl residue, * expresses a carbon which is an asymmetric center) in the presence of sulfuric acid. Optically active 2-piperadinecarboxylic acid or its salt is produced by hydrolyzing the resultant optically active 2-piperadinecarboxamide or its sulfate.