发明名称 |
Factors which modify gene transcription and methods of use therefor |
摘要 |
Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
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申请公布号 |
US5919666(A) |
申请公布日期 |
1999.07.06 |
申请号 |
US19950540804 |
申请日期 |
1995.10.11 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
YOUNG, RICHARD A.;KOLESKE, ANTHONY J.;THOMPSON, CRAIG M.;CHAO, DAVID MIN |
分类号 |
C07K14/395;C07K14/47;C07K16/14;C12N9/12;G01N33/573;(IPC1-7):C12P19/34;C07K1/00 |
主分类号 |
C07K14/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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