| 摘要 |
Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmac eutically acceptable solvates (including hydrates) of either entity, wherein R1 is (A); (B); (C); (D); or CH2CH2NR3R4 (E); R2 is R5 R6C(OH)A or R7COA; R3 is H, C1-C6 alkyl, substituted alkylene, C3-C7 cycloalkyl optionally substituted with HO, C3-C6 alkenyl optiona lly substituted with aryl, C5-C7 cycloalkenyl or C3-C6 alkynyl; R4 is H or C1-C6 alkyl; R5 and R6 are each independently selected from H, C1-C6 alkyl, C1-C4 perfluoroalkyl and C3-C7 cycloalkyl, or, together with the carbon atom to which they are attached, from a 3- to 7-mem bered carbocyclic or optional heterocyclic ring; R7 is C1-C6 alkyl, substituted alkylene, C3-C7 cycloalkyl or aryl; A is a direct link or optionally C1-C4 alkyl branched C1-C6 alkylene or C2-C6 alkenylene; and k is 0, 1 or 2; are selective 5-HT1-like agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
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