发明名称 |
Constitutive expression of non-infectious hiv-like particles |
摘要 |
Non-infectious, non-replicating immunogenic HIV-like particles are produced by stable long-term constitutive expression in mammalian cells by eliminating elements toxic to the mammalian cells. An expression vector contains a nucleic acid molecule comprising a modified HIV genome devoid of long terminal repeats and wherein Tat and vpr sequences are functionally disabled and a constitutive promoter operatively connected to the modified HIV genome for constitutive expression of the modified genome to produce the HIV-like particles. |
申请公布号 |
AU1657799(A) |
申请公布日期 |
1999.07.05 |
申请号 |
AU19990016577 |
申请日期 |
1998.12.14 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
BENJAMIN ROVINSKI;FEI-LONG YAO;SHI XIAN CAO |
分类号 |
C12N15/09;A61K39/21;A61P31/18;C07K14/16;C12N7/00;C12N15/49 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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