| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound, having amidino group modified with a specific substituent group and strong inhibiting actions on the blood platelet aggregation and excellent effectiveness by the peroral administration, remarkably improved in solubility in various solvents and useful for preventing and treating thrombosis. SOLUTION: This compound is represented by formula I [A is CON(R<1> ) or N(R<1> )CO (R<1> is H or a 1-4C alkyl); D<2> and D<3> are each C atom; A is bonded to D<2> or D<3> ; B is CH2 or O; X is CH or N; Z is H or a (substituted) alkyl; R<2> to R<4> are each H, a 1-4C alkyl, propargyl, etc.], e.g. 7-[[4-(morpholinoiminomethyl)benzoyl]-amino]-1,2,3,4-tetrahydronaphtha lene-2- acetic acid. The compound is preferably obtained by carrying out the condensation reaction of, e.g. p-cyanobenzoic acid (chloride) with a compound represented by formula II or III [E is HN(R<1> )] and converting cyano group of the resultant compound represented by formula IV into a substituted amidino group. |
