PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS

摘要

Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C1-4)alkyl optionally substituted; R1 is (C1-6)alkyl or polyfluoro(C1-6)-alkyl; R2 is (C4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N}O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF alpha inhibitors.