A PACKAGING CELL LINE PRODUCING SIV-PSEUDOTYPED MLV

摘要

The present invention relates to a packaging cell line packaging an MLV-based recombinant retroviral genome into a particle comprising an SIV envelope, and a pseudotyped retroviral particle produced by the packaging cell line. Both, the packaging cell line and the retroviral particle, when comprising therapeutic genes, are especially useful for somatic gene therapy, preferably in mammals including humans.