NMR APPARATUS AND METHOD FOR NON-INVASIVE IN-VIVO TESTING OF A PATIENT'S BODY FLUID GLUCOSE LEVELS

摘要

A magnet assembly (10) for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, comprising two permanent magnets (11) facing one another, a tapered pole cap (12) on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized annular canceling magnets (18) disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. Also provided is a method for in vivo measurement of glucose concentration in a patient's body fluid using NMR spectroscopy. The method comprises spectral editing, e.g. double quantum filtering to isolate scalar coupled resonances of glucose.