| 发明名称 |
COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES |
| 摘要 |
Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).
|
| 申请公布号 |
CA2314980(A1) |
申请公布日期 |
1999.07.01 |
| 申请号 |
CA19982314980 |
申请日期 |
1998.12.17 |
| 申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
BOEHM, JEFFREY CHARLES;GALLAGHER, TIMOTHY FRANCIS;ADAMS, JERRY LEROY |
| 分类号 |
A61K31/506;A61K31/5377;A61P29/00;A61P31/12;A61P43/00;C07D401/14;C07D403/04;C07D403/14;(IPC1-7):A61K31/505;C07D413/14;A61K31/535 |
主分类号 |
A61K31/506 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
