METHOD FOR QUANTITATING DENATURED LDLS

摘要

An assay method commonly usable in the clinical field whereby denatured LDLs such as oxidized LDL contained in the body fluids of patients with arteriosclerosis, hyperlipemia, etc. can be conveniently detected and quantitated in an intact state at a high sensitivity; and a fused polypeptide to be used as a constituent in the above assay method, which is composed of the extracellular region of a mammalian oxidized LDL receptor and a part of the heavy chain of a mammalian immunoglobulin. This fused polypeptide per se is useful as the active ingredient in drugs for preventing and treating arteriosclerosis, hyperlipemia, etc.