发明名称 |
IFNAR2/IFN COMPLEX |
摘要 |
The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon .alpha./.beta. receptor (IFNAR). Such a complex also improves the stability of the IFN and enhances the potency of the IFN. The complex may be a non-covalent complex or one in which the IFN and the IFNAR are bound by a covalent bond or a peptide. When bound by a peptide bond in the form of a fusion protein, the IFN may be separated from the IFNAR by means of a peptide linker. Such a fusion protein may be produced by recombinant DNA technology. Storing IFN in the form of such a complex improves the storage life of the IFN and permits storage under milder conditions than would otherwise be possible.
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申请公布号 |
CA2311648(A1) |
申请公布日期 |
1999.07.01 |
申请号 |
CA19982311648 |
申请日期 |
1998.12.18 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
CUNNINGHAM, MARK;MCKENNA, SEAN;TEPPER, MARK;EL TAYAR, NABIL;SHERRIS, DAVID |
分类号 |
C12N15/09;A61K38/00;A61K38/21;A61P31/12;A61P35/00;A61P37/02;A61P43/00;C07K14/56;C07K14/565;C07K14/715;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/02;C12P21/04;(IPC1-7):A61K38/21;A61K38/17;C07K14/555 |
主分类号 |
C12N15/09 |
代理机构 |
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