发明名称 |
TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE |
摘要 |
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides. |
申请公布号 |
WO9931969(A2) |
申请公布日期 |
1999.07.01 |
申请号 |
WO1998US27056 |
申请日期 |
1998.12.18 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION;NEUHOLD, LISA, ANN;KILLAR, LORAN, MARIE |
发明人 |
NEUHOLD, LISA, ANN;KILLAR, LORAN, MARIE |
分类号 |
A01K67/027;A61K45/00;A61P19/02;A61P19/04;A61P29/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|