摘要 |
An efficient and scalable method is reported for the isolation of costatolide (2), an HIV-1-specific nonnucleoside reverse transcriptase inhibitor (NNRTI), from the latex of Calophyllum plants such as C. teysmannii var. inophylloide. An overall yield of 10.6 % of costatolide, with a purity of 96 %, was obtained by repetitive recrystallization of the latex from a single organic solvent after the oily material was removed by treatment with hexane. A second major component of the latex, soulattrolide (3), another HIV-1 NNRTI, was also isolated. Both compounds were characterized by spectroscopic and chromatographic analyses and their in vitro anti-HIV activities were also confirmed. The results suggest that sufficient supplies of costatolide can be obtained in a relatively low-cost manner from natural sources. |
申请人 |
SARAWAK MEDICHEM PHARMACEUTICALS, INC.;LIN, YUH-MEEI;ANDERSON, HERBERT, M.;JENTA, TUAH, R.;WILLIAMS, MICHAEL, J.;FLAVIN, MICHAEL, T.;XU, ZE-QI |
发明人 |
LIN, YUH-MEEI;ANDERSON, HERBERT, M.;JENTA, TUAH, R.;WILLIAMS, MICHAEL, J.;FLAVIN, MICHAEL, T.;XU, ZE-QI |