发明名称 |
WIP, A WASP-ASSOCIATED PROTEIN |
摘要 |
Described herein is a novel and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA (see Figures 1A-1B); nucleic acid probes, which can be fragments of the WIP gene or WIP cDNA or full-length; nucleic acid primers, which are fragments of WIP cDNA or the WIP gene; methods of assessing cells (e.g., for diagnostic purposes) for the presence of WIP DNA, (e.g., wildtype or mutated) or for the absence or occurrence of a reduced level of WIP DNA; WIP mRNA; WIP or WIP fragments, such as those which are useful to generate antibodies which bind WIP; and antibodies which bind WIP. Also the subjects of this invention are methods of treating conditions in which WIP and/or WASP DNA or protein is deficient (in quantity) and/or defective (e.g., mutated/altered) such that an individual is adversely affected (e.g., has Wiskott-Aldrich Syndrome); methods of altering or regulating WASP and its functions; and methods of altering actin content, actin polymerization or both in cells, such as human lymphoid cells (e.g., beta lymphocytes). A further subject of this invention is an assay to identify drugs which alter (e.g., enhance) the activity of WIP or expression of WIP DNA. |
申请公布号 |
WO9932628(A2) |
申请公布日期 |
1999.07.01 |
申请号 |
WO1998US27501 |
申请日期 |
1998.12.22 |
申请人 |
CHILDREN'S MEDICAL CENTER CORP.;RAMESH, NARAYANASWAMY;ANTON, INES, M.;HARTWIG, JOHN, H.;GEHA, RAIF, S. |
发明人 |
RAMESH, NARAYANASWAMY;ANTON, INES, M.;HARTWIG, JOHN, H.;GEHA, RAIF, S. |
分类号 |
C07K14/47;C12N15/12 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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