SYNTHESIS OF DIAMINES

摘要

A solid phase method for producing a compound comprising an unsubstituted or substituted diamine moiety, which method comprises: (i) reacting an N-protected amino aldehyde with an amino group attached to a solid resin to produce a resin-bound enamine product; and (ii) reducing the enamine product to produce a resin-bound N-protected diamine. The resin bound diamine may be further modified for example by further protection, reaction with an amino acid or by carrying out solid phase peptide synthesis to provide a peptide bonded at its C-terminus to a diamine moiety.