发明名称 |
New method of preparation of finasteride. |
摘要 |
<p>Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17 beta -carboalkoxy-4-aza-5 alpha -androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.</p> |
申请公布号 |
GR3029554(T3) |
申请公布日期 |
1999.06.30 |
申请号 |
GR19990400546T |
申请日期 |
1999.03.04 |
申请人 |
MERCK & CO. INC. |
发明人 |
DOLLING, ULF H.;MCCAULEY, JAMES A.;VARSOLONA, RICHARD J. |
分类号 |
A61K31/58;C07F3/00;C07J73/00;C07J75/00;H04N5/74;(IPC1-7):C07J73/00 |
主分类号 |
A61K31/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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