| 摘要 |
N,N'-disubstituted amide derivatives having potent and selective antagonistic action to 5-HT3 receptor have been developed by the present invention, which provides antagonistic drugs to 5-HT3 receptor containing novel N,N'-disubstituted amide derivatives represented by a general formula ¢I! (see fig. I) (wherein R1 denotes a hydrogen atom or lower alkyl group, R2 and R3, which may be identical or different, denote respectively a hydrogen atom, lower alkyl group, lower alkenyl group, nonsubstituted or substituted aryl-lower alkyl group, acyl group or lower alkoxycarbonyl group, R4 denotes a hydrogen atom, lower alkyl group or lower alkoxy group, A denotes CH or N, and n denotes 1, 2 or 3), their hydrates or acid addition salts.
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