发明名称 |
CELL SPECIFIC CYTOTOXIC AGENTS DERIVED FROM DIPHTHERIA TOXIN |
摘要 |
This invention relates to a modified diphtheria toxin (DT) and method of preparing the same in which two carboxy-terminal truncated forms of DT are prepared by specific chemical proteolysis generating two new proteins HA51DT and HA48DT which can be chemically linked to a cell specific binding moiety to produce potent cytotoxins. This invention further relates to carboxy terminal peptides formed in accordance with said proteolysis generating three peptides HA11DT, HA7DT and HA3DT.
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申请公布号 |
CA1340612(C) |
申请公布日期 |
1999.06.29 |
申请号 |
CA19890593101 |
申请日期 |
1989.03.08 |
申请人 |
THE UNIVERSITY OF WYOMING |
发明人 |
VILLEMEZ, CLARENCE L.;MYERS, DEAN A. |
分类号 |
A61K38/00;A61P3/08;A61P29/00;A61P31/12;A61P33/10;A61P35/00;A61P37/00;A61P37/06;C07K1/113;C07K14/00;C07K14/195;C07K14/34;C07K14/41;C07K14/42;C07K16/00;C07K19/00;(IPC1-7):C07K14/34;A01N63/02;A61K47/48 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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