PRODUCTION OF N-ALKYLPYRIDINEMETHANAMINE COMPOUNDS

摘要

PROBLEM TO BE SOLVED: To obtain the subject compound in a high yield in simple operation and mild conditions capable of inhibiting the generation of by-products by reacting a cyanopyridine compound with a monoalkylamine and hydrogen in the presence of a noble metal catalyst as a hydrogenation catalyst. SOLUTION: (B) A cyanopyridine compound preferably a cyanopyridine of formula I [R is an alkyl; (n) is an integer of 0-4]} is reacted with (C) a monoalkylamine [preferably a monoalkylamine of the formula: R'NH2 (R' is an alkyl)] and (D) hydrogen to obtain (E) an N-alkylpyridinemethanamine (preferably an N-alkylpyridinemethanamine of formula II). The component A is used in an amount of 0.1-2.0 wt.% per wt.% of the component B. Thereby, the objective compound can be obtained in a high yield by the reaction under a low hydrogen pressure without performing a special reaction operation.