| 摘要 |
PCT No. PCT/DE94/00314 Sec. 371 Date Sep. 12, 1995 Sec. 102(e) Date Sep. 12, 1995 PCT Filed Mar. 17, 1994 PCT Pub. No. WO94/21240 PCT Pub. Date Sep. 29, 1994New superparamagnetic particles useful in medicine for destroying tumors, increasing immunity and diagnosing conditions are disclosed. For that purpose, very small superparamagnetic single-domain particles are aggregated and protected against further aggregation by chemical bonding of reactive stabilizer substances on the surface of the superparamagnetic particles. These new particles thus consist of stable, decomposable aggregates with a particle size in a range between 10 and 1000 nanometers and a defined behavior in a magnetic field. The aggregates consist of several small superparamagnetic single-domain particles of iron oxide, iron mixed oxide or iron, with a particle size in a range between 3 and 20 nanometers, bearing on their surface chemically bound organic substances from the group comprising the phosphate, diphosphate, polyphosphate, thiophosphate, phosphonate or group containing polyalkylene glycols, phosphate group containing nucleotides, their oligomers or polymers, as well as phosphate group containing carbohydrates, which may present further binding sites. Both the new disclosed superparamagnetic aggregates and reactive stabilizer substances may be active substances.
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