摘要 |
Provided are compounds of the formula depicted and including the N-oxide form, salts and sterochemically isomeric forms thereof having PDE IV inhibiting activity as well as cytokine inhibiting activity. R1 and R2 are independently hydrogen, alkyl, difluoromethyl, trifluoromethyl, cycloalkyl, heterocyclic radical, alkylsulfonyl, arylsulfonyl, aralkyl or heterocyclic substituted alkyl; R3 is hydrogen, halo or alkoxy; R4 is hydrogen, halo, optionally substituted alkyl, cycloalkyl, carboxyl, alkoxycarbonyl, cycloalkylaminocarbonyl, aryl or hetercyclic radical; or R4 is -O-R6 or -NH-R7; R5 is hydrogen, halo, hydroxy or alkyl; or R4 and R5 taken together may form a bivalent alkylene radical optionally interrupted with O or NR8; Y is a bond, haloalkanylene or alkanylene; A-B is an optionally substituted bivalent ethyl or ethenyl hydrocarbon radical; and L is hydrogen, alkylcarbonyl, alkoxycarbonyl, an optionally substituted alkyl, alkenyl, arylalkenyl an optionally substituted piperidinyl, alkylsulfonyl or arylsulfonyl.
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