发明名称 |
COMPOUDS EFFECTIVE IN INDUCING CELL DIFFERENTIATION AND PROCESS FOR PREPARING SAME |
摘要 |
This invention provides novel side chain homologs of 1.alpha.,25-dihydroxyvitamin D3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.
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申请公布号 |
CA1340615(C) |
申请公布日期 |
1999.06.29 |
申请号 |
CA19890597715 |
申请日期 |
1989.06.25 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
PERLMAN, KATO L.;KUTNER, ANDRZEJ;DELUCA, HECTOR F.;SCHNOES, HEINRICH K. |
分类号 |
A61K31/59;A61P35/00;C07C401/00;C07F7/18;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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